Introduction: With the development and widely use of HER2 targeted therapies, HER2 expressing metastatic breast cancer have no longer dismal prognosis as once expected.The combination of HER2 targeted therapies with chemotherapatic agents prolongs overall survival.Pertuzumab is a new monoclonal antibody molecule that binds to the extracellular port
In 2020, the COVID-19 pandemic brought tourism to an abrupt halt.Supply-side stakeholders suddenly found themselves hp pavilion 15-eg1053cl in a lockdown with unusable assets, unprofitable investments and jobs in jeopardy.Using qualitative research, we take a closer look at how they dealt with this unprecedented crisis in the Slovenian urban destin
The genus Strychnos (Loganiaceae) is well-known as a rich source of various bioactive metabolites.In continuation of our phytochemical studies on plants from Amazonia, we examined Strychnos aff.darienensis, collected in Peru.This species has been traditionally used in South America and is still presently used as a drug by the Yanesha tribe in Peru.
Abstract Narcolepsy is a chronic sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep paralysis.This disease affects significantly the overall patient functioning, interfering with social, work, and affective life.Some symptoms of narcolepsy depend on emotional stimuli; for instance, cataplec
Artificially stimulated, high-yield microbial production of methane from coal is a challenging problem that continues to generate research interest.Decomposition of organic matter and production of methane from coal are the results of multiple redox reactions carried out by different communities of bacteria and archaea.Recent work by our group (Bec